Would cold creme interfer with my syrum and moisturizer?

I would think that it would.  I don’t know if you mean chemically but the best judge of that would be to ask the people who make your serum and moisturizer.  But in general, I am not sure why you are using cold crème, unless it is to take off your makeup.  I think that since cold crème is so heavy, it would be good to wash it off with your cleanser after you have removed all your makeup.  Most foundation should wash off with cleanser and warm water.  The eyes can be cleansed with makeup remover of cold crème, if you like.